PD29-02: The association of preconception paternal metabolic syndrome on early childhood emergency department visits and hospitalization: analysis of U.S. claims data

Saturday, September 11, 2021 8:00 PM to 10:00 PM
Abstract

Information

Authors: Tony Chen, Chiyuan Zhang, Shufeng Li, Gary Shaw, Alan Schroeder, Michael Eisenberg

Introduction: Increasing preconception paternal comorbidity has been associated with adverse pregnancy outcomes including pregnancy loss and preterm birth. However, the relationship between a father’s health on the child after birth remains uncertain.  In the present study, we examined the association of preconception paternal health with emergency department (ED) visits and hospitalizations of the children.

Methods: The IBM Marketscan Research database comprises of inpatient and outpatient healthcare claims from private, employer-insured individuals. Family groups were generated within Marketscan linking children born to paired fathers and mothers covering within the United States between 2009–2016. Within these groups, relevant ICD-9, ICD-10, CPT, and Diagnosis Related Group codes were used to query paternal and maternal metabolic syndrome (MetS) component diagnoses (hypertension, diabetes, hyperlipidemia, and obesity), and hospitalization and ED visit rates for offspring within the first two years of life. Models were adjusted for birth year, region, offspring sex, maternal and paternal age, maternal MetS, prematurity, NICU requirement, low birth weight, time of follow-up, and parental smoking status. All analyses were performed in SAS software version 9.4 (SAS Institute).

Results: During the observation period, 295,355 boys and 278,735 girls were born with 34.9% of children having at least one emergency room visit and 6.0% of children having an inpatient admission. After adjustment, the odds of inpatient admission and ED visits increased in a dose-dependent fashion among fathers with higher comorbidities. The child of a father with two MetS components was 13% more likely to require hospitalization in the first two years of life (95% CI 1.08-1.19) compared to the child of a father with no MetS components. Similarly, the child of a father with three or more MetS components was 22% more likely to have at least one emergency room visit (95% CI, 1.15-1.29) and 48% more likely to have had three or more ED visits (95% CI, 1.36-1.61) compared to a father with no components of MetS. Moreover, the association persists across maternal health strata.

Conclusions: Increasing paternal preconception comorbidity is associated with a higher risk that a child requires ED and inpatient care in the first years of life. Whether the association is due to biologic, lifestyle, or a combination of factors, an opportunity exists to engage men in preconception counseling to optimize health.

Source of Funding: National Institutes of Health National Center for Advancing Translational Science Clinical and Translational Science Award (UL1 TR001085)
Therapeutic Area
Infertility